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Michael Jai White

Al Simmons / Spawn

Martin Sheen

Jason Wynn

John Leguizamo

Clown / Violator

Theresa Randle

Wanda Blake

Nicol Williamson

Cogliostro

D. B. Sweeney

Terry Fitzgerald

Melinda Clarke

Jessica Priest

Miko Hughes

Zack

Sydni Beaudoin

Cyan

Michael Papajohn

Glen, Zack's Dad

Frank Welker

The Devil Malebolgia (voice)

Tony Haney

African Liaison

Todd McFarlane

Bum

Simon Rhee

Hong Kong Military Air Base Person (uncredited)

Robia LaMorte

XNN Reporter

John Cothran

African Liaison

Caroline Gibson

News Anchor

Marc Robinson

Punk #1

Chris Coppola

Punk #2

Jay Caputo

Punk #3